Cortiva® 1mm allograft dermis
Many ways to operate
Surgeons can rely on the consistent 1mm thickness of Cortiva® 1mm allograft dermis, available in three configurations — non-perforated, perforated, and pre-shaped — to suit a range of surgical needs in shape and size.

One thickness, three unique options

With precise thickness consistency, Cortiva® 1mm allograft dermis provides a predictable option for excellent handling.1,2,3,6,†
A novel configuration in Evergen's Cortiva® 1mm allograft dermis portfolio featuring a distinctive pattern of hexagonal perforations.
Cortiva® 1mm Tailored allograft dermis is designed to enhance surgical precision and support patient-centric customization.11
Each graft features a uniform 1mm thickness with tight specification tolerances, ensuring consistent, predictable handling and optimal pliability and conformability.1

Level 1 clinical evidence

In a prospective randomized controlled trial of 302 patients, outcomes with Cortiva® 1mm allograft dermis (151 patients) were compared to outcomes with AlloDerm RTM (151 patients). The study noted that the odds of seroma formation were almost 2-fold higher with AlloDerm RTM than with Cortiva® 1mm allograft dermis (p=0.047) after adjustment for relevant covariates.2,†
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3-6x faster fluid drainage with unique perforated design

A modified Franz cell test comparing how long it took for 500 mL of fluid to pass through 6-by-6-centimeter samples of Cortiva® 1mm Perforated allograft dermis, FlexHD Pliable Perforated, Thin, and AlloDerm RTM Perforated shows a 3-6x times faster drainage rate with Cortiva® 1mm Perforated allograft dermis.1

Drainage time per 500ml

Cortiva® 1mm
Perforated allograft dermis
25 sec
FlexHD Pliable
Perforated, Thin
93 sec
AlloDerm RTM
Perforated
152 sec
Lab data may not be representative of effects or performance in humans.

Rapid revascularization

Pre-clinical results1,*
(100x)

In pre-clinical studies of cellular infiltration and histology, capillary formation was observed as early as 7 days post implantation along with a favorable immune response consistent with normal wound healing.1,*

Clinical results3,†
(100x)

In a clinical setting, 13 patients underwent a second planned procedure where the graft
was biopsied, and robust revascularization and incorporation were observed.3,†
Images: Representative Masson’s Trichrome

Surgical graft options

With precise thickness consistency and multiple sizes to choose from, Cortiva® 1mm allograft dermis provides a predictable option for excellent handling.1,2,3,6,†

Thickness

0.8-1.0mm

Rehydration time

At least 30 seconds

Tolerance

+/- 0.1mm

Size options

4 x 12cm to 16 x 20cm

Dermal cut

Dermis without basement membrane

Cortiva® 1mm allograft dermis
DH2412
4 x 12cm
DH2416
4 x 16cm
DH2508
5 x 8cm
DH2612
6 x 12cm
DH2616
6 x 16cm
DH2710
7 x 10cm
DH2812
8 x 12cm
DH2816
8 x 16cm
DH2820
8 x 20cm
DH3015
10 x 15cm
DH3620
16 x 20cm
A novel configuration featuring a distinctive pattern of hexagonal perforations. Hexagonal perforations were shown to give greater multi-directional expansion compared to other perforation shapes.4,*

Thickness

0.8-1.0mm

Rehydration time

At least 30 seconds

Tolerance

+/- 0.1mm

Size options

16 x 20cm

Dermal cut

Dermis without basement membrane

Cortiva® 1mm Perforated allograft dermis
DP1620
16 x 20cm
Designed for a better fit, Cortiva® 1mm Tailored allograft dermis supports greater surgical precision and patient-centric customization.5

Thickness

0.8-1.0mm

Rehydration time

At least 30 seconds

Tolerance

+/- 0.1mm

Size options

7.3 x 15.1cm to 10.2 x21.1cm

Dermal cut

Dermis without basement membrane (no orientation)

Cortiva® 1mm Tailored allograft dermis
DMS087
Small, 7.3 x 15.1cm (87 cm2)
DMM140
Medium, 9.2 x 19.2cm (140cm2)
DML170
Large, 10.2 x 21.1cm (170cm2)

Coordinate implant ordering with your local representative:

800-624-7238

customerservice@evergenbio.com
References
  1. Data on file at Evergen.
  2. Keane AM, et al. "Cortiva vs AlloDerm in Prepectoral and Partial Submuscular Implant-Based Breast Reconstruction: A Randomized Clinical Trial." Plast Reconstr Surg. 2023 Dec 12.
  3. Moyer, et. al. 2017. "A histological comparison of two human acellular dermal matrix products in prosthetic-based breast reconstruction." Plastic and Reconstructive Surgery Global Open, December 2017, 5(12).
  4. Lake, S. et. al., "Pore size and pore shape – but not mesh density – alter the mechanical strength of tissue ingrowth and host tissue response to synthetic mesh materials in a porcine model of ventral hernia repair." Journal of the Mechanical Behavior of Biomedical Materials 42(2015) 186-197.
  5. Kanchwala, S. Holton, T. Momeni, A. (2024, February 22). KOL discussion & feedback.
  6. Keifer OP Jr, et al. "A Complication Analysis of 2 Acellular Dermal Matrices in Prosthetic-based Breast Reconstruction." Plast Reconstr Surg GlobOpen. 2016 Jul 13;4(7):e800.
* Performance data from animal models may not be representative of performance in humans.
† Clinical cases are unique and individual results may vary.
DESCRIPTION
Cortiva® 1mm, Cortiva® 1mm Tailored, Cortiva® 1mm Perforated, and Cortiva Silhouette® allograft dermis are dehydrated dermis from donated human tissue processed through the Tutoplast® tissue sterilization process. The implants are preserved by the Tutoplast® tissue sterilization process which retains the three-dimensional collagen structure responsible for the multidirectional, mechanical properties of the original dermal tissue. These implants are regulated as 361 human cell and tissue product (HCT/Ps) as defined in US FDA 21 CFR 1271 and are restricted to homologous use for the repair, replacement, reconstruction or augmentation of soft tissue by a qualified healthcare professional (e.g., physician). These implants are provided sterile and require rehydration prior to use.
WARNINGS
CORTIVA SILHOUETTE, CORTIVA 1MM PERFORATED, CORTIVA 1MM: The same potential medical/surgical conditions or complications that apply to any surgical procedure may occur during or following implantation. The surgeon is responsible for informing the patient of the risks associated with their treatment and the possibility of complications or adverse reactions. As with any human tissue implant, the potential for transmission of infectious agents may exist. A small number of patients may experience localized immunological reactions to the implant. Successful treatment is dependent upon the patient’s host tissue response. Resorption of the implant and commensurate substitution with functional host tissue is required to restore function. CORTIVA SILHOUETTE: Do not use the implant for abdominal wall repair, hernia repair or for other procedures that require substantial tensile strength. The implant should be used only where it is under minor to moderate tension. CORTIVA 1MM PERFORATED: Do not use the implant for abdominal wall repair, hernia repair or for other procedures that require substantial tensile strength. The implant should be used only where it is under minor to moderate tension. Do not further perforate the implant. Additional perforations may affect implant performance. CORTIVA 1MM TAILORED: The same medical/surgical conditions or complications that apply to any surgical procedure may occur during or following implantation. The surgeon is responsible for informing the patient of the risks associated with their treatment and the possibility of complications or adverse reactions. As with any human tissue implant, the potential for transmission of infectious agents may exist. A small number of patients may experience localized immunological reactions to the implant. Successful treatment is dependent upon the patient’s host tissue response. Resorption of the implant and commensurate substitution with functional host tissue is required to restore function.
PRECAUTIONS
Prior to use, the surgeon must become familiar with the implant and the surgical procedure. Poor general medical condition or any pathology that would limit the blood supply and compromise healing should be considered when selecting patients for procedures using this implant; as such conditions may compromise outcomes. The implant should be used with caution in surgical sites where an active infection is present or in sites with poor perfusion. If the surgeon determines that the clinical circumstances require implantation in a site that is contaminated or infected, appropriate local and/or systemic anti-infective measures should be taken. Appropriate placement and fixation of the implant are critical to the success of the surgical procedure.
All Cortiva® and Cortiva Silhouette® allograft dermis implants are processed by RTI Surgical, Inc. (Alachua, FL).

Please refer to the labeling for complete instructions for use.
Regulatory approvals vary by country. Therefore, we kindly ask you to contact the distributor in your region regarding availability of specific products in your region.

® indicates U.S. trademark registration. All trademarks and/or images are the property of their respective owners or holders.
© Evergen 2025 / RTI Surgical, Cook BioTech and Collagen Solutions are now Evergen. All rights reserved.
‍
Distributed by:
Evergen
11621 Research Circle
Alachua, FL 32615 USA
T 877.343.6832
evergenbio.com
DESCRIPTION
Cortiva® 1mm, Cortiva® 1mm Tailored, Cortiva® 1mm Perforated, and Cortiva Silhouette® allograft dermis are dehydrated dermis from donated human tissue processed through the Tutoplast® Tissue Sterilization process. The implants are preserved by the Tutoplast® tissue sterilization process which retains the three dimensional collagen structure responsible for the multidirectional, mechanical properties of the original dermal tissue. These implants are regulated as 361 human cell and tissue product (HCT/Ps) as defined in US FDA 21 CFR 1271 and are restricted to homologous use for the repair, replacement, reconstruction or augmentation of soft tissue by a qualified healthcare professional (e.g.,physician). These implants are provided sterile and require rehydration prior to use.
WARNINGS
CORTIVA SILHOUETTE, CORTIVA 1MM PERFORATED, CORTIVA 1MM: The same potential medical/surgical conditions or complications that apply to any surgical procedure may occur during or following implantation. Thesurgeon is responsible for informing the patient of the risks associated with their treatment and the possibility of complications or adverse reactions. As with any human tissue implant, the potential for transmission of infectious agents may exist. A small number of patients may experience localized immunological reactions to the implant. Successful treatment is dependent upon the patient’s host tissue response. Resorption of the implant and commensurate substitution with functional host tissue is required to restore function. CORTIVA SILHOUETTE: Do not use the implant for abdominal wall repair, hernia repair or for other procedures that require substantial tensile strength. The implant should be used only where it is under minor to moderate tension. CORTIVA PERFORATED: Do not use the implant for abdominal wall repair, hernia repair or for other procedures that require substantial tensile strength. The implant should be used only where it is under minor to moderate tension. Do not further perforate the implant. Additional perforations may affect implant performance CORTIVA 1MM TAILORED: The same medical/surgical conditions or complications that apply to any surgical procedure may occur during or following implantation. The surgeon is responsible for informing the patient of the risks associated with their treatment and the possibility of complications or adverse reactions. As with any human tissue implant, the potential for transmission of infectious agents may exist. A small number of patients may experience localized immunological reactions to the implant. Successful treatment is dependent upon the patient’s host tissue response. Resorption of the implant and commensurate substitution with functional host tissue is required to restore function.
PRECAUTIONS
Prior to use, the surgeon must become familiar with the implant and the surgical procedure. Poor general medical condition or any pathology that would limit the blood supply and compromise healing should be considered when selecting patients for procedures using this implant; as such conditions may compromise outcomes. The implant should be used with caution in surgical sites where an active infection is present or in sites with poor perfusion. If the surgeon determines that the clinical circumstances require implantation in a site that is contaminated or infected, appropriate local and/or systemic anti-infective measures should be taken. Appropriate placement and fixation of the implant are critical to the success of the surgical procedure.
Cortiva® allograft dermis and Cortiva Silhouette® are processed by RTI Surgical, Inc. (Alachua, FL).

Please refer to the labeling for complete instructions for use.
Regulatory approvals vary by country. Therefore, we kindly ask you to contact the distributor in your region regarding availability of specific products in your region.

® indicates U.S. trademark registration. All trademarks and/or images are the property of their respective owners or holders.
© Evergen 2025 / RTI Surgical, Cook BioTech and Collagen Solutions are now Evergen. All rights reserved.
‍
Distributed by
Evergen
11621 Research Circle
Alachua, FL 32615 USA
T 877.343.6832
evergenbio.com